Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Lyme Disease Clinical Trials
Lyme Disease clinical trials are recruiting across 15 cities. Here are the cities with the most active studies:
Lyme Disease Trial Phases
6 research organizations are sponsoring lyme disease trials.
About Lyme Disease
Lyme disease is a tick-borne infection caused by Borrelia burgdorferi bacteria, causing rash, fever, and potentially joint, heart, and neurological problems if untreated. Early treatment with antibiotics is highly effective. Research is ongoing for chronic Lyme symptoms and vaccine development.
Clinical trials are advancing new treatments for lyme disease. Currently, 11 studies are recruiting a combined 3,360 participants across the United States. Research is being conducted by 6 organizations including Pfizer, National Institute of Allergy and Infectious Diseases (NIAID), Icahn School of Medicine at Mount Sinai and 3 others.
2026 Lyme Disease Research Landscape
As of July 2026, the lyme disease clinical trial landscape includes 11 actively recruiting studies across 15 cities in the United States. These studies are collectively seeking 3,360 participants, with an average enrollment target of 305 per study.
The research spans multiple phases of development: 3 studies are in NA, 2 studies are in PHASE1, 2 studies are in PHASE2, 1 study is in PHASE3, 1 study is in EARLY_PHASE1. The presence of Phase 3 trials indicates that some lyme disease treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 6 different organizations, including Pfizer, National Institute of Allergy and Infectious Diseases (NIAID), Icahn School of Medicine at Mount Sinai, Columbia University, State University of New York - Upstate Medical University, and 1 others.
Geographically, lyme disease trials are most concentrated in New York, New York (4 trials); Bethesda, Maryland (3 trials); Washington D.C., District of Columbia (2 trials); Bangor, Maine (1 trial); Worcester, Massachusetts (1 trial) and 7 other cities.
Featured Lyme Disease Studies
Highlighted recruiting studies for lyme disease, selected by enrollment size and research scope.
A Study to Learn About the Safety, Tolerability, and Immunogenicity of a Fifth Dose of 6-Valent OspA-Based Lyme Disease Vaccine
The purpose of this study is to learn about the safety effects of the Lyme disease vaccine (called VLA15), and its ability to protect people from Lyme disease after a 5th dose of the vaccine. This study is seeking participants who: * are generally healthy and 7 years of age and older, * have already been vaccinated with 4 doses of VLA15 (from the VALOR study), and have blood sample taken post do...
A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations
This study will determine whether patients who have been infected with the Lyme bacteria, Borrelia burgdorferi, and treated with antibiotics still have the bacteria alive inside them and whether it is causing their symptoms. The information from this study may serve as a basis for developing stringent diagnostic criteria for Lyme disease and the establishment of future treatment trials. Individua...
Evaluation, Treatment, and Follow-up of Patients With Lyme Disease
This study is designed to establish a population of patients with Lyme disease for evaluation, treatment and follow-up to learn more about the infection. Patients with active Lyme disease may be eligible for this study. Participants will have a medical history and physical examination and diagnostic evaluations as appropriate to their individual condition. Laboratory tests may include routing bl...
Frequently Asked Questions About Lyme Disease Clinical Trials
Are there lyme disease clinical trials near me?
Yes, there are 11 lyme disease clinical trials currently recruiting across 15+ cities in the United States, including New York, New York; Bethesda, Maryland; Washington D.C., District of Columbia. Browse the studies above to find one at a location convenient for you.
How do I join a lyme disease clinical trial?
To join a lyme disease clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are lyme disease clinical trials free?
Yes, participation in lyme disease clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of lyme disease treatments are being studied?
Current lyme disease clinical trials are testing a range of approaches across NA (3 studies), PHASE1 (2 studies), PHASE2 (2 studies), PHASE3 (1 study), EARLY_PHASE1 (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 6 research organizations.
Is it safe to participate in lyme disease clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 17, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 17, 2026 · Data from ClinicalTrials.gov