8 Sarcoma Clinical Trials in Philadelphia, PA (2026)

Q: How do I join a clinical trial in Philadelphia?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you.

Recruiting Sarcoma Studies in Philadelphia

NCT05910307Recruiting

Synovial Sarcoma Registry / Biospecimen Repository

The purpose of this study is to collect and store data and samples for future research to attempt to improve outcomes for patients with synovial sarcoma. The future research will involve various types...

Philadelphia, PA1,000 participantsChildren's Hospital of Philadelphia

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NCT06263231Recruiting

A Study to Investigate Efficacy & Safety of Intratumoral INT230-6 Compared to US Standard of Care in Adults With Soft Tissue Sarcomas (INVINCIBLE-3)

To compare Overall Survival (OS) for INT230-6 vs United States (US) Standard of Care (SOC) in participants with unresectable or metastatic liposarcoma, undifferentiated pleomorphic sarcoma or leiomyos...

Philadelphia, PAPHASE3333 participantsIntensity Therapeutics, Inc.

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NCT05918640Recruiting

Lurbinectedin in FET-Fused Tumors

The purpose of this study is to find out if a drug called lurbinectedin (the "study drug") is safe and effective at treating people with recurrent or relapsed solid tumors, including Ewing sarcoma....

Philadelphia, PAPHASE163 participantsChildren's Hospital of Philadelphia

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NCT06436846Recruiting

Genomic Risk in Retroperitoneal Sarcoma

The protocol intends to explore the biology which may underlie recurrences of retroperitoneal liposarcoma. Surgery remains the only curative intent intervention for this disease. Often, tumors recur i...

Philadelphia, PA50 participantsFox Chase Cancer Center

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NCT07297979Recruiting

Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS)

The main objectives of this trial are to determine the recommended dose for expansion of xaluritamig (dose confirmation part only) and to determine the safety and tolerability of xaluritamig in adult,...

Philadelphia, PAPHASE150 participantsAmgen

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NCT04305691Recruiting

Trial of Ixazomib for Kaposi Sarcoma

This phase II trial studies how well ixazomib works in treating patients with Kaposi sarcoma. Ixazomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth....

Philadelphia, PAPHASE241 participantsAIDS Malignancy Consortium

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NCT06156410Recruiting

Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas

The purpose of this study is to better understand how safe and effective the drug cabozantinib in combination with high-dose ifosfamide is in the treatment of children and adults with relapsed/refract...

Philadelphia, PAPHASE130 participantsChildren's Hospital of Philadelphia

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NCT07436364Recruiting

Application of Contrast-enhanced Ultrasound in Monitoring Soft Tissue Sarcoma Response to Neoadjuvant Radiotherapy

This pilot study will evaluate the feasibility of applying CEUS as imaging guidance for planning RT and predicting RT response. The investigators will determine if US-CT/MRI fusion is feasible and if ...

Philadelphia, PAEARLY_PHASE110 participantsThomas Jefferson University

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About Sarcoma Clinical Trials in Philadelphia

Sarcomas are rare cancers that arise in bone and soft tissues including muscle, fat, blood vessels, and connective tissue. There are more than 70 subtypes of sarcoma. Treatment usually involves surgery combined with radiation and/or chemotherapy.

There are currently 8 sarcoma clinical trials recruiting participants in Philadelphia, PA. These studies are seeking a combined 1,577 participants. Research is being sponsored by Children's Hospital of Philadelphia, Intensity Therapeutics, Inc., Fox Chase Cancer Center and 3 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Sarcoma Clinical Trials in Philadelphia — FAQ

Are there sarcoma clinical trials in Philadelphia?

Yes, there are 8 sarcoma clinical trials currently recruiting in Philadelphia, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Philadelphia?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you about next steps.

Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Philadelphia studies also compensate for your time and travel.

What sarcoma treatments are being tested?

The 8 active trials in Philadelphia are testing new therapies including novel drugs, biologics, and treatment approaches for sarcoma.

Data updated August 29, 2026 from ClinicalTrials.gov