15 Brain Cancer Clinical Trials in Philadelphia, PA (2026)

Q: How do I join a clinical trial in Philadelphia?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you.

Recruiting Brain Cancer Studies in Philadelphia

NCT05839379Recruiting

Targeted Pediatric High-Grade Glioma Therapy

The goal of this study is to perform genetic sequencing on brain tumors from children, adolescents, and young adult patients who have been newly diagnosed with a high-grade glioma. This molecular prof...

Philadelphia, PA350 participantsNationwide Children's Hospital

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NCT04732065Recruiting

ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors

This phase I trial studies the effects and best dose of ONC206 alone or in combination with radiation therapy in treating patients with diffuse midline gliomas that is newly diagnosed or has come back...

Philadelphia, PAPHASE1208 participantsSabine Mueller, MD, PhD

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NCT05086497Recruiting

WBSI Guided Personalized Delivery of TTFields

This research study is for Glioblastoma (GBM) patients who will be beginning Optune as part of their clinical care, which is a novel treatment that utilizes - tumor treating fields (TTFields), (aka, e...

Philadelphia, PANA155 participantsAbramson Cancer Center at Penn Medicine

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NCT05843253Recruiting

Study of Ribociclib and Everolimus in HGG and DIPG

The goal of this study is to determine the efficacy of the study drugs ribociclib and everolimus to treat pediatric and young adult patients newly diagnosed with a high-grade glioma (HGG), including D...

Philadelphia, PAPHASE2120 participantsNationwide Children's Hospital

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NCT07282587Recruiting

Study of ONC206 (JZP3507) in Advanced Pheochromocytoma and Paraganglioma

This is a two-stage Phase 2 trial evaluating the efficacy and safety of ONC206 in participants with Pheochromocytoma and Paraganglioma (PCPG)....

Philadelphia, PAPHASE290 participantsJazz Pharmaceuticals

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NCT05278208Recruiting

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

This study will evaluate the safety and efficacy of Lutathera (177Lu-DOTATATE) in patients with progressive or recurrent High-Grade Central Nervous System (CNS) tumors and meningiomas that demonstrate...

Philadelphia, PAPHASE165 participantsNationwide Children's Hospital

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NCT06161974Recruiting

Study of Olutasidenib and Temozolomide in HGG

The goal of this study is to determine the efficacy of the study drug olutasidenib to treat newly diagnosed pediatric and young adult patients with a high-grade glioma (HGG) harboring an IDH1 mutation...

Philadelphia, PAPHASE260 participantsRigel Pharmaceuticals

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NCT05345002Recruiting

All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

This is a Phase II study of the combination of All-Trans Retinonic Acid (ATRA) and PD-1 inhibition (Retifanlimab) in patient with recurrent IDH-mutant glioma. The Sponsor-Investigator hypothesizes tha...

Philadelphia, PAPHASE255 participantsStephen Bagley, MD, MSCE

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NCT05555550Recruiting

Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG

The purpose of this study is to see if 18F-Fluciclovine (Axumin®) is useful and safe in the management of children with Low Grade Gliomas (LGG). Imaging with 18F-Fluciclovine PET-MRI will be performed...

Philadelphia, PAEARLY_PHASE130 participantsChildren's Hospital of Philadelphia

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NCT05553041Recruiting

18F-Fluciclovine PET-MRI in High-grade Glioma

The purpose of this study is to see if 18F-fluciclovine (Axumin®) PET imaging is useful and safe in the management of children with High Grade Gliomas. Investigators seek to determine if this imaging ...

Philadelphia, PAEARLY_PHASE130 participantsChildren's Hospital of Philadelphia

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NCT04655404Recruiting

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

This is a pilot study that will evaluate disease status in children that have been newly diagnosed high-grade glioma with TRK fusion. The evaluation will occur after 2 cycles of the medication (Larotr...

Philadelphia, PAEARLY_PHASE115 participantsNationwide Children's Hospital

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NCT06333899Recruiting

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

The goal of this study is to determine the response of the study drug loratinib in treating children who are newly diagnosed high-grade glioma with a fusion in ALK or ROS1. It will also evaluate the s...

Philadelphia, PAEARLY_PHASE115 participantsNationwide Children's Hospital

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NCT06613841Recruiting

Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma

* To perform metabolic phenotyping of treatment naïve and recurrent GBM by multitracer \[18F\]Fluciclovine and 18F-FDG PET. * To compare uptake measures of 18F-Fluciclovine and 18F-FDG and MRI quantif...

Philadelphia, PAEARLY_PHASE115 participantsAbramson Cancer Center at Penn Medicine

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NCT07209241Recruiting

Different Approaches for CART-EGFR-IL13Ra2 Dosing in Recurrent GBM

This is an open-label, phase 1b study to evaluate different approaches for CART-EGFR-IL13Ra2 dosing and further characterize the safety, feasibility, preliminary efficacy, and pharmacokinetics of CART...

Philadelphia, PAPHASE112 participantsUniversity of Pennsylvania

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NCT06973096Recruiting

CART-EGFR-IL13Ra2 in Newly Diagnosed GBM Following Initial Radiotherapy

This is an open-label phase 1 study to assess the safety, feasibility, pharmacokinetics and preliminary efficacy of autologous T cells co-expressing two CARs targeting the cryptic EGFR epitope 806 and...

Philadelphia, PAPHASE19 participantsUniversity of Pennsylvania

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About Brain Cancer Clinical Trials in Philadelphia

Brain cancer includes tumors that originate in the brain (primary) or spread from other areas (metastatic). Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Treatment typically combines surgery, radiation, and chemotherapy, with immunotherapy trials underway.

There are currently 15 brain cancer clinical trials recruiting participants in Philadelphia, PA. These studies are seeking a combined 1,229 participants. Research is being sponsored by Nationwide Children's Hospital, Sabine Mueller, MD, PhD, Abramson Cancer Center at Penn Medicine and 5 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Brain Cancer Clinical Trials in Philadelphia — FAQ

Are there brain cancer clinical trials in Philadelphia?

Yes, there are 15 brain cancer clinical trials currently recruiting in Philadelphia, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Philadelphia?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you about next steps.

Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Philadelphia studies also compensate for your time and travel.

What brain cancer treatments are being tested?

The 15 active trials in Philadelphia are testing new therapies including novel drugs, biologics, and treatment approaches for brain cancer.

Data updated July 16, 2026 from ClinicalTrials.gov