Philadelphia, PA7 Active Studies

Head and Neck Cancer Clinical Trials in Philadelphia, PA

Find 7 actively recruiting head and neck cancer clinical trials in Philadelphia, PA. Connect with local research sites and explore new treatment options.

7
Active Trials
7
Sponsors
1,028
Enrolling

Recruiting Head and Neck Cancer Studies in Philadelphia

NCT06699212Recruiting

A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases

The goal of this clinical trial is to learn if ASP-1929 photoimmunotherapy (PIT) in combination with pembrolizumab works to treat recurrent squamous cell cancer of the head and neck (HNSCC) with no di...

Philadelphia, PAPHASE3412 participantsRakuten Medical, Inc.
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NCT06030011Recruiting

Implementing the NYU Electronic Patient Visit Assessment (ePVA) for Head and Neck Cancer In Rural and Urban Populations

The PI and the research team developed the New York University (NYU) Electronic Patient Visit Assessment (ePVA) for head and neck cancer (HNC) as a patient-reported outcome measure (PRO) for the early...

Philadelphia, PANA270 participantsThe University of Texas Health Science Center, Houston
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NCT06837480Recruiting

Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema

The U.S. Food and Drug Administration approved photobiomodulation therapy (PBMT) as a treatment for breast cancer-related arm lymphedema (BCRL) in 2006. The investigators conducted two pilot clinical ...

Philadelphia, PANA150 participantsAbramson Cancer Center at Penn Medicine
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NCT07182149Recruiting

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

This study is being done to find out of NRM-823 is safe and can treat participants with locally advanced or metastatic solid tumors....

Philadelphia, PAPHASE1150 participantsNormunity AccelCo, Inc.
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NCT06747390Recruiting

Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery

Based on evidence that the local anesthetic lidocaine may have anticancer effects, this study will assess the safety and efficacy of intratumoral lidocaine injection at the time of direct laryngoscopy...

Philadelphia, PAPHASE130 participantsRyan Carey
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NCT07644585Recruiting

A Pilot Study of Ultra-High Dose Rate (ConformalFLASH®), for Reirradiation of Carcinoma of the Head and Neck

This pilot study is designed to evaluate the feasibility of delivering ultra-high dose-rate conformal proton therapy (ConformalFLASH) in participants requiring re-irradiation for head and neck cancer ...

Philadelphia, PANA10 participantsIBA Proton Therapy, Inc.
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NCT07501650Recruiting

Pembrolizumab Plus Ultrasound-Induced Microbubble Cavitation in Head and Neck Cancer

This is a feasibility trial studying anti-PD-1 therapy (Pembrolizumab) among patients with R/M HNSCC, delivered with ultrasound-induced microbubble cavitation, with the goal of optimizing delivery of ...

Philadelphia, PAPHASE16 participantsThomas Jefferson University
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About Head and Neck Cancer Clinical Trials in Philadelphia

Head and neck cancers develop in the mouth, throat, larynx, sinuses, or salivary glands. HPV-related oropharyngeal cancers have been increasing in prevalence. Treatment includes surgery, radiation, chemotherapy, and immunotherapy.

There are currently 7 head and neck cancer clinical trials recruiting participants in Philadelphia, PA. These studies are seeking a combined 1,028 participants. Research is being sponsored by Rakuten Medical, Inc., The University of Texas Health Science Center, Houston, Abramson Cancer Center at Penn Medicine and 4 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Head and Neck Cancer Clinical Trials in Philadelphia — FAQ

Are there head and neck cancer clinical trials in Philadelphia?

Yes, there are 7 head and neck cancer clinical trials currently recruiting in Philadelphia, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Philadelphia?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you about next steps.

Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Philadelphia studies also compensate for your time and travel.

What head and neck cancer treatments are being tested?

The 7 active trials in Philadelphia are testing new therapies including novel drugs, biologics, and treatment approaches for head and neck cancer.

Data updated October 12, 2026 from ClinicalTrials.gov